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Thank you, great info. Keep posting the pictures!

 

How are you making our with your treatment? I can't find Neribas Cream here in the States. However, I would like to try this cream.

Neribas is just one possible skin moisturising cream you could use.  What is important, is that it contains Disodium EDTA, since this is required as a gelating agent.  I would also recommend using a cream without perfume or any extra 'bells and whistles' to prevent any possible side effects.

Hi,
I want to make the cream myself, but i was wondering what kind of Manganese (II) Chloride to order.
Powder or solution?
Could you let me know which ingredients i should exactly buy. I have this website i'd like to order from:http://www.sigmaaldrich.com/catalog/search?interface=All&term=manganese%20(II)%20chloride&lang=en&region=BE&focus=product&N=0+220003048+219853066+219853286
Thank you very much for your help!!

Manganese(II) chloride in powder and chunks.  You want it as a powder so that it will dissolve more easily

Thank you for your reply... I have some more questions:
1. Where do you order your ingredients... The cream: do you have examples of other creams we can use (with product names). What should i ask for in my pharmacy. (i cannot find the cream you mention).
2. How do you measure everything? as you make very small amounts of cream.
3. How do you mix everything?
4. Is the calcium chloride also as a powder?
6. Sodium bicarbonate as powder?
7. Tips and tricks?
Suggestion> what about an airless pump bottle, available at ebay, this could keep the cream longer in good condition...

1. The ingridients can be bought on the internet.  One website I found - but it is in german, is http://www.omikron-online.de/

2. Using a very fine electronic balance, can also be bought on the internet.

3. As described on this site.

4. Yes

5. Yes

6. Could work. Worth a try

I lately came across your blog and have been learning along. I thought I would leave my first comment. I don't know what to say except that I have enjoyed reading. Nice blog. I will keep visiting this blog very frequently.

Thank you for your reply!
The Omikron site has a lot of different types Manganese (II) Chloride and Calcium Chloride, i'm not sure what to take.
Do you still use the cream and are you still happy with the results?

Old ingredients not PC-KUS

Any idea-where do I search for these ingredients FOR CREAM in India?

Hi how do you order the cream? im gona give it a go : )

tinytash44r@aol.com

do you know any hair product containing EDTA? How much of the product should I mix?

Do you know how much EDTA the cream contains?

Could you possibly provide links to order the correct forms of manganese and calcium chloride?

Thanks!

I have vitiligo for more than 10years now. Will it still work for me?

Do you still using your cream?
Your first photo is from spring of 2011, have you some new?
I try mix it and start using. It will be great if it works.

It will be tough to get the manganese II chloride because pertinent information is needed to order. Need to have a legitimate reason, and a home experiment may not cut the mustard. All the other ingredients are easily attainable. Cetaphil would probably be a good substitute for Neribas. Just make sure you get the creme with the disodium edta. An electronic balance can be found on EBAY for around $15. Like the author said, be careful with the manganese chloide. To make 100 grams of product, use 380 mg of mag chlor. If making 10 grams of product, use 38 mg of mag chlor. Very important to ration to scale. If anybody has tried this for gray hair, please offer results. As soon as I can get some mag chlor, I will try it in a limited area (maybe back of neck, and/or on facial hair in one area). I'm thinking the sun would take care of the UV light.

Hi,

I really want to make the cream for myself for treatment of gray hair. The dermatologist here told me it would cost $90 every month to order the premade stuff. Can you tell me if making it myself would be more cost effective? And if so, can you please tell me where I can order the ingredients?

Thank you.

Hello

Iamadmin: What's exactly written on your Manganese chloride and calcium chloride bags ? Is it MnCl2,4H2O and CaCl2, 2H2O ? Or is it MnCl2 and CaCl2 without H2O ?
In other words, is it MnCl2 tetrahydrate, dihydrate or anhydrous ? (And the same about CaCl2) ?
That shoud be written on your boxes.

Thank you very much for your help.

Hi anybody knows if vit c is essential in helping pigmentation along with the cream?

THe ingredients listed is for the old cream. P-Cat not PC-KUS

I was wondering that if you are buying manganese (II) chloride from a chemical company, why not just buy manganese (II) carbonate and calcium carbonate and forgoe the chemical reaction? They cost roughly the same price and there would be less steps to make the cream.

Under more ideas you mention possible hair greying solution. Why do you not suggest addign the other CREAM ingredients to a edta hair product. Such as the baking soda?

Thanks so much for the website. You have listed so much valuable information and am glad that I happened to stumble upon it. I did want to note that I originally started with a "Folic Acid and B-vitamin complex" daily supplement and saw significant repigmentation during the summer months. However, it was not beneficial to areas that were not being exposed to the sun. I have since started the pseudocatalase regimen and am trying to make sure to get the adequate sun exposure weekly. It has been 4 weeks and I am beginning to see the early signs of repigmentation!! Thanks again for all your due diligence on the site.

It appears that optimum catalytic activity is obtained at about 0.5% by weight of EDTA (opposed to 0.1% w/w in the original formulation). Have you had any success finding the concentrations of disodium EDTA in various products? Also, as noted in your formula.....catalytic activity is proven to be increased when the chelating agent (Disodium EDTA) is added to the ions of the transition metal before adding the bicarbonate ions.

I tried getting Manganese (II) Chloride (the hardest ingredient to get). That's a dead end in the United States. Unless you are a university or chemical company you cannot purchase it from chemical suppliers. You can find one here and there, but its rare. I purchased a pound of 99.8% pure manganese for $22 shipped. Here is where I went metalshipper(dot)com. You can then mix it with muriatic acid or hydrochloric acid (same thing) to make manganese (II) chloride. Check YouTube for detailed instructions. I am a chemistry student and this is easy to do. Just trying to help everyone in the States.

Has anyone tried buying the cream from www.pseudocatalase.com? I was gona attempt to make it but it looks really hard to do : ( x

I have ordered it online and have also driven to their pharmacy since they are 30 minutes from my job. Tried it almost 1 year and absolutely didn't improve. I noticed infact one of the spots on the elbow has slight grown. Freaked me out totally.
I had originally bought it thinking it was the German Pseudocatalase (P-KUS) but it isn't the same formula or product.
I have add those darn spots for 27 years and they still bother me!

I found a website that sells manganese (II) chloride but it says it is mainly used for production of dry cell batteries. Is that right or is that to harsh for the skin?

The recipes for the vitiligo creams I've seen sold online all include melon extract as a vital ingredient [melons are being used to extract an enzyme superoxide dismutase (SOD)].
For instance
Vitiderm Gel Active ingredients:
- Concentrated melon
- Ginkgo Biloba
- Calcium Chloride
Ingrédients 
Aqua, Propylene Glycol, Alcohol, Peg-40 Hydrogenated Castor Oil, Carbomer, Cucumis Melo Fruit Extract, Ginkgo Biloba Leaf Extract, Cholecalciferol, Glycerin, Calcium Chloride, Parfum, Potassium Sorbate, Sodium Hydroxide, Citric Acid, Sodium Benzoate, Methylchloroisothiazolinone, Methylisothiazolinone, Limonene, Linalool.

VitiDerm® Gel Depigmentation regulator available from dispensing chemists OCP : ACL 9968447

About cantaloupe melons:

• The fruit contains moderate levels of B-complex vitamins, such as niacin, pantothenic acid and vitamin C, and minerals like manganese. Consumption of foods rich in vitamin-C helps the human body develop resistance against infectious agents and scavenge harmful oxygen-free radicals. Manganese is used by the body as a co-factor for the antioxidant enzyme, superoxide dismutase. Commercially, muskmelons are being used to extract an enzyme superoxide dismutase (SOD), which plays a vital role as strong first-line antioxidant defenses inside the human body.
• The fruit is an excellent source of Vitamin A, (100 g provides 3382 IU or about 112% of recommended daily levels) one of the highest among fruits. Vitamin A is a powerful antioxidant and is essential for vision. It is also required for maintaining healthy mucus membranes and skin. Consumption of natural fruits rich in vitamin A is known to help to protect from lung and oral cavity cancers.
• It is also rich in antioxidant flavonoids such as beta-carotene, lutein, zea-xanthin and cryptoxanthin. These antioxidants have the ability to help protect cells and other structures in the body from oxygen-free radicals and hence; offer protection against colon, prostate, breast, endometrial, lung, and pancreatic cancers.
• Total antioxidant strength measured in terms of oxygen radical absorbance capacity (ORAC) of cantaloupe melons is 315 µmol TE/100 g. The value for honeydew melon is 241 µmol TE/100 g.
• Zea-xanthin, an important dietary carotenoid, selectively absorbed into the retinal macula lutea in the eye where it is thought to provide antioxidant and protective UV light-filtering functions. It thus, offers protection of eyes from "Age-related macular degeneration" (ARMD) disease in the elderly.
• It is a moderate source of electrolyte, potassium. 100 g fruit provides 267 mg of this electrolyte. Potassium is an important component of cell and body fluids and helps control heart rate and blood pressure. It thus offers protection against stroke, and coronary heart diseases.

Cantaloupe nutrition facts
Nutritional value per 100 g (3.5 oz) Energy 141 kJ (34 kcal) Carbohydrates 8.16 g - Sugars 7.86 g - Dietary fiber 0.9 g Fat 0.19 g Protein 0.84 g Vitamin A equiv. 169 μg (21%) - beta-carotene 2020 μg (19%) - lutein and zeaxanthin 26 μg Thiamine (vit. B1) 0.041 mg (4%) Riboflavin (vit. B2) 0.019 mg (2%) Niacin (vit. B3) 0.734 mg (5%) Pantothenic acid (B5) 0.105 mg (2%) Vitamin B6 0.072 mg (6%) Folate (vit. B9) 21 μg (5%) Choline 7.6 mg (2%) Vitamin C 36.7 mg (44%) Vitamin K 2.5 μg (2%) Calcium 9 mg (1%) Iron 0.21 mg (2%) Magnesium 12 mg (3%) Manganese 0.41 mg (20%) Phosphorus 15 mg (2%) Potassium 267 mg (6%) Sodium 16 mg (1%) Zinc 0.18 mg (2%)

As one can see melons contain manganese. Manganese does not contain melon obviously. Does Manganese alone work?

Well i have managed to gather all of the ingredients and just got a bit confused on the mix -

so it says:

To produce 100 grams of the cream you need the following ingredients:

380mg of Manganese (II) Chloride
200mg of Calcium Chloride (approximately)
a few drops of distilled water
2.3g of Sodium Bicarbonate (Baking Soda) ............. is this the same as 2,300mg? ?
100g of Neribas cream or a similar cream containing Disodium EDTA........... and 100,000mg??

Wouldnt this equal to more than 100g of cream?

Thank you look forward to hearing back as i am waiting to mix : )

@ Jude. I think the administrator isn't answering questions anymore, so I will help you as much as possible. Ive been waiting for months on an answer. I wouldn't worry about the final weight of the ingredients mixed. They will only add 2.88 grams to the 100g Neribas cream giving a final yield of 102.88 grams including the Neribas cream. Close enough to 100g. Also, 2.3 grams of sodium bicarbonate is equal to 2300mg. The conversion from grams to milligrams is 3 decimal places. So, 100 grams is equal to 100,000 milligrams. I recommend a high quality digital scale accurate to .001 grams. Cheers.

Hi dave, thanx for replying back to me. I went ahead and mixed the cream anyway just over a month ago and have been applying it about twice a day and also using the uvb lamp, so far I have seen positive results, especially on My knees which have had tiny brown dots of pigment coming back through! So something is working!! Did u manage to make up any cream?

I'm a bit worried about the manganese content of the cream. According to the link provided, the tolerable upper limit RDA is 11mg or 0.011g. The cream contains 380mg of manganese / 100g of cream, that's 3.8mg per 1g of cream. Correct me if I'm wrong (and I well could be as my math is terrible), 3g of cream is over the tolerable limit as in 3g of cream there would be 11.4mg manganese?

Yes, so don't eat it...!

The intake through your skin into the bloodstream should be minimal if any.

http://askanesthetician.wordpress.com/2013/03/19/do-your-skincare-products-get-absorbed-into-your-bloodstream/

What do you think of pseudocatalse creams on Amazon? Have ordered some. Appreciate the information you have put out on your website. It has given m some confidence.

Is there an difference between this recipe and pc-kus?

Which is better?

http://www.ebay.com/itm/10g-Pseudocatalase-PC-KUS-Recently-Reported-to-T...

Would you be able to make a video showing where you are getting the ingredients for the USA, How you are putting it together, and how you are measuring everything out?

Hi!
How much water do I need to add?
Thank you!

Cetaphil cream contains disodium EDTA .Can I use this for preparing P C cream.

I got the MANGANESE CHLORIDE TETRAHYDRATE - MnCl2*4H2O and the Calcium Chloride Anhydrous > 99 % both on ebay.co.uk. The other ingredients you can get in any supermarket. Look on hand creams or body lotions for containing disodium EDTA. I bought the supermarkets own brand that contained it. A little electronic scale i got in a general store (make sure it measures mgs and not just grams). Everything cost me in total less than 30euros. If you don't want to make 100g at a time as the cream is not stable, divide the amounts in half and make 50g so it doesnt go 'off'. I made it and it actually seems to be working. I see small spots of colour appearing on my hands and feet:)

If anyone is interested, I found a really good website with information on pigmentary disorders. It's http://www.skinwhiteningscience.com

Hello bro, firstly many thanks to you for this wonderful website.
I have a small patch on lip and genital. Do u think Pseudocatalase cream will be able to re-pigment those area? I bought Pseudocatalase cream from here http://www.ebay.com/itm/10g-Pseudocatalase-PC-KUS-Recently-Reported-to-T.... I have been using this for 1.5 month but still no re-pigmentation.I mixed it with a JOHNSON'S® Baby Lotion,since I didnt find other products in my country, which is mild and simple. Can I mix the powder directly with water and use it.

I did a lot of research and i like an idea that vitiligo is autoimune disease, basically it is you body being allergic to your melanocites, like in alopecia you are allergic to your hair folicules.
So i was wondering how does allergy drug work with vitiligo, especially immune system suppressants?
More, can drugs that are used with organ transplant that suppress immune system have any impact on vitiligo?
and finally, if vitiligo is allergy why not treat it like every allergy by eliminating the cause , there is some theory that when we were evolved to live with parasites and when we eradicated parasites from our bodies our immune system got "bored" and does some stupid stuff like reacting to pollen or dust, so i was wondering can this be used to treat vitiligo: http://en.wikipedia.org/wiki/Helminthic_therapy

btw. thanks for your effort and not trying to make money out of our bad luck, like some bad people do :(

It's better if you use a Neribas Cream (Amazon.com).

Recently a friend of mine let me know about a new vitiligo cure research. When I started reading about it, I realized that the Doctor’s theory answers most of the doubts, if not all of them.
Before checking it out, be prepared to break paradigms, since he states that the main cause of non-segmental vitiligo is not the immune system, but friction (physical stress).
My son is 13 years old and he has vitiligo since 9. I have taken him to most of the medical specialties in order to find all the vitiligo puzzle pieces, but it seems that I’m not going to get anywhere.
Read in english: w w w . researchforvitiligo . com
option=com_content&view=article&id=370&Itemid=243
I also had a chance to speak with Doctor Matteo Bondignon (researcher) and I would like to share with you, but check out links above first…
I said:
“We all know that vitiligo is a symptom of something wrong from inside. I’ve been working hard to find the right diet and supplementation for my son. I’ve been also taking him to an UVB-NB phototherapy treatment. We did all the allergy tests, we treated dysbiosis, we checked thyroid and emotional stress. I reduced the oxidative streess as much as I could.
But since my son loves soccer and guitar, his hands and feet have most of his vitiligo, which has been spreading. It seems to be caused by the friction (physical stress).
Instead of removing MIA, what can we do to make the melanocyte adhesion stronger?
What should I supplement my son to give melanocyte better resistence against MIA?
I think that would be the right solution, since it would focus the cause, not the effect.
His answer:
“As for my studies, there is not currently any linkage from something inside us and the development of vitiligo.
Everything start from the MIA protein and as you say friction is one of the most causative element.
It is not possible to make the adhesion molecoles stronger because this strongness is genetically provided. That ‘s why the only way to cure definitively vitiligo is to eliminate or anyway to rend inoffensive the MIA protein.
We are working hard on this and I hope that soon your son can get his skin of one color.
Thanks for your support and please help us to share the knowledge about the MIA protein and the new hope for all the patients suffering from vitiligo.”

First of all, thank you very much for providing this useful information. I fear it is not spread widely enough, as I meet people with vitiligo every now and then.
Secondly, I'm sorry for any mistakes made. Please try to overlook them, as I provide a usefull feedback for vitiligo treatment :-)

About me: at the age of 23 I first saw white spots or better said "less brown" skin around my mouth. At that time I used to sunbath a lot. I thought it might be due to sunoil not covering all areas. At the age of 25 I burned my self very much while beeing on vacation. At that time I knew something was wrong. Doctors told me there is no cure.
At age 27 I started to hate the white spots, maybe induced by a breakup and difficulties with finding a new girlfriend. "What is that?" -"Well....". In addition to that, exposure to sun in spring 2015 showed me, the white spots not only spreaded but started spreading at many more spots.
It pissed me off, so I decided to look for answers. I met a woman who had vitiligo but was recovering, with many pigments in wide white areas. She told me about Prof. Schallreuter. Googling her I somewhat encountered this page! It never was my intention to take a long vacation for a doctor's appointment, so I decided to first try the tipps provided here.

And guess what my experience with the creme is: it works! Which is far better than expected, to be honest. Though I respect the work of both professors, I think it is a lot of money for that cure (100€ per bottle - you'll need some of those!). As I think vitiligo affects one's life a lot, I don't appreciated to take a lot of money from people that are desperate for a cure. In this context, I am very unpleased how many scammers excist and probably take money from desperate people.

Enough of that, here is what I've done, based on the information provided here, in the patent (which is linked somewhere on this page) and after having talked to some people treated by Professor Schallreuter.

I bought "Fenjal Sensitive" or so bodylotion at my local drug store. First I googled which product contains as little "unhealthy" stuff as possible BUT contains disodium edta. Which is crucial (!) for good treatment (stated in the patent). This cream costs 3,-€ per 400g. Don't just buy something expensive!
I then bought at a local chemist store CaCl (containing NO water, 500g), that backing soda thing (salt?)(Natrumhydrogencarbonat in german, 1000 g), MnCl2 tetrahydrat (100g) for less than 40,- €.
That destilled water costs almost nothing and the needed mixing stuff is usually a one-time-purchase. I think it cost me around 30,-€. Additionally I use little muffin-forms to measure the weight. All ingredients can be looked up on this page! As of now and looking at the amount of chemicals left, I'd say these will provide me with creme for another 2 years. So 40€ + 3€ per bottle = maybe 5€ per bottle of creme. In the long term!

Long story short, mixing is easy, only part difficult is measuring these small amounts. For 400g creme it's a little more easy. I usually use that 400g in 2-3 weeks, until I mix a new creme.

Sometimes I use it twice a day, sometime once and some days not even once. I'd say I roughly use the creme 5 times per week. It obviously does NOT matter at what time you use the UV-B. I used the creme for about a month before I invested ~300,-€ in a small hand-UV-B (311 nm) device. I use this device twice a week, since it takes a long time to apply the UV-B to every part of the body. But investing 3000€ for a bigger device doesn't make sense to me.

To sum it up: 5 times per week creme, 2 times per week UV-B and the occasional sun (5 minutes cloudy! per day). I use the cream on every part of my body but I am very careful with my eyes. It contains a high amount of salt, which you can smell and feel. After 1-2 hours I take a shower and wash it all off. Professor Schallreuter told one of her patients to not use perfume if possible, thus I mostly use perfume free soap for sensitive skin.

And I see results! It's been 3 to 4 months at most, the spreading has stopped and repigmentation (island-like growth) has begun. I hope this inspires others to try and treat their vitiligo, if it bothers them. Please see this as a hopefully helpfull comment, all thanks go to the creator of this page!

Kind regards and many thanks
Dennis

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